SAMe is used by your body in three important pathways: contributing methyl groups to activate certain molecules. Synthesis of polyamines (for cell growth, gene expression, neuronal regeneration). Trans-sulphuration (synthesis of cysteine, glutathione and other sulphate chemicals). SAMe occurs naturally in your body and is concentrated in the liver and brain. It is a major methyl donor in the synthesis of hormones, nucleic acids, proteins and phospholipids. SAMe is also required for the synthesis of norepinephrine, dopamine and serotonin, and plays a role in other intracellular metabolic pathways. SAMe facilitates glutathione usage and maintains acetylcholine levels. That, in turn, helps to enhance or maintain cognitive function and attenuate or prevent aggression of ageing and neurodegeneration. SAMe should not be taken by those diagnosed with bipolar disorder. Keep out of reach of children. Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store tightly closed in a cool and dry place.