Product Description
Although there are numerous books on drug metabolism Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug’s absorption distribution metabolism and excretion (ADME). Covering traditional and recent technologies and applications the book takes a strong industrial approach discussing the basics of scintillation counting and untangling the various data processing methods often specific to individual manufacturers. The chapters include descriptions of the latest micro-plate counters and the growing applications of accelerator mass spectrometry positron emission tomography gamma-scintigraphy and radioluminography. In addition to describing how the analytical technologies work the contributors explain how the data are interpreted and used in the drug registration process. A unique reference and training aid essential for every drug metabolism department or drug metabolism research team the book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving easily across the boundaries of biology chemistry and physics this is the only comprehensive interdisciplinary resource covering the how-tos of employing radiotracers in drug development. It provides detailed information on how the science is relevant to the registration process.
Crc Press Radiotracers In Drug Development 09780367453725
Although there are numerous books on drug metabolism Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug’s absorption distribution metabolism and excretion (ADME). Covering traditional and recent technologies and applications the book takes a strong industrial approach discussing the basics of scintillation counting and untangling the various data processing methods often specific to individual manufacturers. The chapters include descriptions of the latest micro-plate counters and the growing applications of accelerator mass spectrometry positron emission tomography gamma-scintigraphy and radioluminography. In addition to describing how the analytical technologies work the contributors explain how the data are interpreted and used in the drug registration process. A unique reference and training aid essential for every drug metabolism department or drug metabolism research team the book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving easily across the boundaries of biology chemistry and physics this is the only comprehensive interdisciplinary resource covering the how-tos of employing radiotracers in drug development. It provides detailed information on how the science is relevant to the registration process.
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